Description

Pase 2mg (Clonazepam)

Indications

Pase 2mg (Clonazepam) is used for the treatment of panic disorder, with or without agoraphobia. Panic disorder typically involves sudden, unexpected panic attacks and ongoing worry about future episodes.

Pase 2mg is also prescribed for certain seizure disorders, either on its own or alongside other treatments. These include:

• Lennox–Gastaut Syndrome

• Akinetic and myoclonic seizures

• Absence seizures (when other treatments have not worked)

Long-term use (beyond 9 weeks) has not been extensively studied, so doctors are advised to review each patient’s progress regularly.

Use this medication only under the advice of a registered healthcare professional.

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Pharmacology

Clonazepam is a benzodiazepine that helps calm excessive activity in the brain. It works by enhancing the action of GABA, a natural neurotransmitter that reduces nerve activity. This results in:

• Anticonvulsant effects

• Sedation

• Muscle relaxation

• Reduction in anxiety

Clonazepam also shows effects on serotonin pathways. It is effective in both generalised and focal epilepsies, helping stabilise abnormal electrical activity in the brain.

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Dosage & Administration

Oral Use (Adults)

Seizure Disorders:

• Start with 1.5 mg per day, divided into 3 doses.

• Increase by 0.5–1 mg every 3 days, based on response.

• Maximum daily dose: 20 mg.

Panic Disorder:

• Start with 0.25 mg twice daily.

• Increase to 1 mg per day after 3 days if needed.

For Children

• Dose is based on weight: 0.01–0.03 mg/kg/day, divided into 2–3 doses.

Injection Use (for emergency settings)

Given via IV or IM by healthcare professionals only.

Always follow your doctor’s instructions. Never adjust the dose or stop treatment suddenly.

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Interactions

Pase 2mg may interact with other medicines, especially those affecting the central nervous system. Always inform your doctor about:

• Anticonvulsants

• Alcohol

• Sleeping pills

• Anti-anxiety medication

• Other benzodiazepines

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Contraindications

Do not use Pase if you have:

• Allergies to benzodiazepines

• Significant liver disease

• Acute narrow-angle glaucoma

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Side Effects

Common side effects include:

• Drowsiness

• Dizziness

• Loss of coordination

• Behavioural changes

• Confusion or memory issues

• Eye movement disturbances

• Mood changes

These may reduce as the body adapts to the medication.

Seek medical help if symptoms become severe.

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Pregnancy & Breastfeeding

Pase may pose risks during pregnancy and can pass into breast milk.

• Use only if the benefits outweigh the risks.

• High doses late in pregnancy may affect the newborn (e.g., breathing issues, low muscle tone).

• Breastfeeding is generally not recommended while taking Pase.

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Precautions & Warnings

• May worsen certain types of seizures if multiple seizure types exist.

• Must be used carefully with valproic acid, as it may trigger absence status.

• Elderly patients may be more sensitive to side effects.

• Dose adjustments may be needed in liver disease.

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Use in Special Populations

Children:

May increase saliva and bronchial secretions — airway monitoring is important.

Elderly:

More sensitive to benzodiazepine effects; lower doses are recommended.

Renal Impairment:

No dose change usually required.

Hepatic Impairment:

Use with caution; dose adjustments may be necessary.

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Overdose Information

Symptoms may include:

• Excessive sleepiness

• Confusion

• Slurred speech

• Loss of coordination

• Breathing problems

• Coma (rare)

Treatment involves supportive care. In severe cases, flumazenil may be used under specialist supervision.

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Therapeutic Class

Benzodiazepine anticonvulsant / adjunct anti-epileptic.

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Storage Conditions

Store in a cool, dry place away from heat and sunlight.
Keep out of reach of children at all times.

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Frequently Asked Question

➤ Is Pase 2 mg a sleeping pill?
No. It is not intended as a sleeping tablet and may actually affect sleep patterns.

➤ Can I take it long-term?
Only if your doctor approves. Long-term use should be reviewed regularly.

➤ Are there withdrawal symptoms?
Stopping suddenly may cause anxiety, sweating, tremors, or difficulty sleeping. Always taper gradually.

➤ Does it affect memory?
It may cause issues with forming recent memories.

➤ Does it cause weight changes?
Some people may experience weight gain or loss.

➤ Can I take it with alcohol?
No. Alcohol increases drowsiness and breathing risks.

➤ Can it interact with other medicines like zolpidem or quetiapine?
Yes — combining can increase drowsiness and impair breathing. Avoid unless advised by a doctor.

➤ Is it habit-forming?
Yes, benzodiazepines can cause dependence. Use the lowest dose for the shortest period necessary.

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Quick Tips

• Avoid driving until you know how Pase affects you.

• Do not drink alcohol while taking this medication.

• Never stop taking it suddenly.

• Report mood or behaviour changes to your doctor immediately.

• Do not use in pregnancy or breastfeeding unless absolutely necessary.